What is the CAS number for IXABEPILONE?

The CAS number of IXABEPILONE is 219989-84-1.

What is IXABEPILONE (219989-84-1) used for?

Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM). It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms'' tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells. Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.InChI:InChI=1/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

What is the CAS number for IXABEPILONE?

The CAS number of IXABEPILONE is 219989-84-1.

What is IXABEPILONE (219989-84-1) used for?

Ixabepilone is an epothilone with broad-spectrum anticancer activity against a panel of 21 cancer cell lines (IC50s = 1.4-34.5 nM). It stabilizes and induces the polymerization of microtubules and induces cell cycle arrest during mitosis. Ixabepilone is cytotoxic to HCT116/VM46 and A2780Tax clonogenic cells, which are resistant to paclitaxel (; IC90s = 16 and 12.3 nM, respectively, for colony growth inhibition). In vivo, ixabepilone (6.3 and 10 mg/kg, i.v., respectively) shows antitumor activity in paclitaxel-resistant human Pat-21 breast carcinoma and HCT116/VM46 colon carcinoma mouse xenograft models with log cell kill (LCK) values of 1.6 and 2.4, respectively. Ixabepilone (10 mg/kg, i.v.) also increases the time for tumors to quadruple in volume by 7.2, 9, 6.5, 4.7, and >10 weeks, respectively, in mice implanted with Rh18 rhabdomyosarcoma, NB1643 neuroblastoma, WT5 Wilms'' tumor, OS29 osteosarcoma, and BT29 brain carcinoma cells. Formulations containing ixabepilone have used in the treatment of metastatic breast cancer.InChI:InChI=1/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

Your Location: Home > Pharmaceutical > IXABEPILONE

IXABEPILONE

Cas number：219989-84-1
purity：99%

Post inquiry

Product Details

Quality Factory Sells Top Purity 99% IXABEPILONE 219989-84-1 with Safe Delivery We supply high quality IXABEPILONE (CAS 219989-84-1), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the IXABEPILONE ?

IXABEPILONE is , while it's Molecular Formula is C27H42N2O5S. Antineoplastic; antimitotic.

How to get the best price on IXABEPILONE?

Shenzhen Konrad Biological Technology Co., LTd is a quality supplier and manufacturer of IXABEPILONE . You can buy high quality, low price IXABEPILONE 219989-84-1 here. Contact us.



IXABEPILONE

CAS:219989-84-1

Purity:99%

Contact Now

We will contact you as soon as possible

Pharmaceutical

Home

About

Product

Pharmaceutical

Others

News

Get in Touch

IXABEPILONE

What is the IXABEPILONE ?

How to get the best price on IXABEPILONE?

IXABEPILONE

Contact Now