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Hydralazine hydrochloride

Cas number：304-20-1
purity：99%

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What is the Hydralazine hydrochloride ?

Hydralazine hydrochloride is white crystalline solid, while it's Molecular Formula is C8H9ClN4. Hydralazine is a non-nucleoside analog that inhibits DNA methylation and reactivates the expression of tumor suppressor genes. Non-selective MAO-A/B inhibitor; semicarbazide-sensitive amine oxidase inhibitor. Antihypertensive.

What is the CAS number for Hydralazine hydrochloride ?

The CAS number of Hydralazine hydrochloride is 304-20-1.

More information of Hydralazine hydrochloride 304-20-1 are:

Synonyms	1(2H)-Phthalazinone,hydrazone, monohydrochloride (9CI);Phthalazine, 1-hydrazino-,monohydrochloride (8CI);(Phthalazin-1-yl)hydrazine hydrochloride;1-Hydrazinophthalazine hydrochloride;1-Hydrazinophthalazine monohydrochloride;Apresoline hydrochloride;Apulon;Hydralazine chloride;Hydralazine monohydrochloride;Lopres;Hydralazine hcl;
CAS?Number	304-20-1
Molecular Formula	C8H9ClN4
Molecular Weight	196.639
Density	1.2961 (rough estimate)
Melting Point	273 °C
Boiling Point	491.9 °C at 760 mmHg
Flash Point	251.3 °C
HS CODE	29339900
PSA	63.10000
LogP	1.72400

What is Hydralazine hydrochloride (304-20-1) used for?

Hydralazine is an orally bioavailable vasodilator and antihypertensive agent. It decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate (PMA; ) at a concentration of 100 μM. Hydralazine (100 μM) also decreases nitric oxide production and mRNA expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS (Item Nos. 19660| 19661| 19662) and interferon-γ (IFN-γ). It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine (; IC50s = 2.2 and 3.06 mM, respectively). Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats. Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.

InChI:InChI=1/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H/p-1

Articles related to Hydralazine hydrochloride:

Article

Source

Synthesis and characterization of various alkyl, aryl and hetero aryl substituted hydrazines and study of their biological activity

Gupta, Anil,Goklani, Poonam

, p. 1041 - 1044 (2017)

Manufacture of pure hydralazine salts

Page/Page column 4; 6, (2008/06/13)

How to get the best price on Hydralazine hydrochloride?

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