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(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine
- Cas number：868540-16-3
- purity：99%
Product Details
Quality products?make an important contribution to long-term revenue and profitability. Factory Sells Best Quality (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine 868540-16-3 with USP
1.What is the (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine ?
(S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
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868539-99-5
C2 HF3 O2 *C26 H35 N3 O4
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868540-16-3
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C
2: lithium hydroxide monohydrate / methanol / 3 h / 0 - 20 °C
With
lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane;
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875309-92-5
(S)-benzyl 2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamido)-3-phenylpropanoate
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868540-16-3
(S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenyipropanoic acid
| Conditions | Yield |
|---|---|
|
With
methanol; hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
for 2h;
under 760.051 Torr;
|
|
|
With
palladium on activated charcoal; ammonium formate;
In
methanol;
at 25 - 30 ℃;
for 2h;
Solvent;
Reagent/catalyst;
|
77 g
|
|
With
5 mol% Pd/C; hydrogen;
In
methanol;
for 0.5h;
|
2.What is the CAS number for (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine ?
The CAS number of (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is 868540-16-3.
More information of (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine 868540-16-3 are:
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CAS?Number |
868540-16-3 |
|
Density |
1.190±0.06 g/cm3(Predicted) |
|
Boiling Point |
865.6±65.0 °C(Predicted) |
|
PSA |
137.07000 |
|
LogP |
2.88980 |
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Pka |
3.50±0.10(Predicted) |
3.What are another words for (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine ?
Synonyms?for?(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine 868540-16-3:(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine;(alphaS) - alpha - [(4 - acetyl Morpholine base) aMino] benzene ding acyl - L - bright aMMonia acyl - L - phenylalanine;L-Phenylalanine, (αS)-α-[[2-(4-Morpholinyl)acetyl]aMino]benzenebutanoyl-L-leucyl-;(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzene;(S)-2-((S)-4-Methyl-2-((S)-2-(2-MorpholinoacetaMido)-4-phenylbutanaMido)pentanaMido)-3-phenylpropanoic acid;Carfilzomib intermidate
4.What is the molecular formula of (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine?
The chemical formula of ?(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is?C31H42N4O6 which containing 31 Carbon atoms,42 Hydrogen atoms,4 Nitrogen atoms and 6 Oxygen atoms,and the molecular weight of??(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine?is 566.698.
5.What is (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine (868540-16-3) used for?
(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine, also known as (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid, is a complex organic compound that serves as an intermediate in the synthesis of Carfilzomib (C183460). (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine plays a crucial role in the development of second-generation proteasome inhibitors, which are significant in the field of oncology.
Used in Pharmaceutical Industry:
(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine is used as an intermediate compound for the synthesis of Carfilzomib, a second-generation proteasome inhibitor. It is utilized for the development of treatments targeting relapsed and refractory multiple myeloma, a type of blood cancer. (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine contributes to the creation of drugs that can effectively combat this disease by inhibiting the activity of the proteasome, a cellular component essential for the degradation of damaged or unneeded proteins. This inhibition can lead to the accumulation of misfolded proteins, ultimately triggering cell death in cancerous cells.
Relevant articles related to (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine:
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Article |
Source |
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Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors |
Lei, Meng,Zhang, Haoyang,Miao, Hang,Du, Xiao,Zhou, Hui,Wang, Jia,Wang, Xueyuan,Feng, Huayun,Shi, Jingmiao,Liu, Zhaogang,Shen, Jian,Zhu, Yongqiang , p. 4151 - 4162 (2019/08/07) |
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PROCESS FOR THE PREPARATION OF (2S)-N-((S)-1-((S)-4-METHYL-1-((R)-2-METHYL OXIRAN-2-YL)-1-OXOPENTAN-2-YLCARBAMOYL)-2-PHENYLETHYL)-2-((S)-2-(2-MORPHOLINO ACETAMIDO)-4-PHENYLBUTANAMIDO)-4-METHYLPENTANAMIDE |
- , (2016/11/14) |
6.Buy (alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine with the best price .
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(alphaS)-alpha-[(4-Morpholinylacetyl)aMino]benzenebutanoyl-L-leucyl-L-phenylalanine
CAS:868540-16-3
Purity:99%
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