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1.What is the Anacetrapib ?
An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.
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875551-28-3
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl
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![(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one](/upload/2026/7/760b4f167cfc4afd8cfaf89f77c83440_7fd67e37-7fc2-4f73-8ba3-b407e5bbf63b.png)
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875444-08-9
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
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875446-37-0
anacetrapib
| Conditions | Yield |
|---|---|
|
With
tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 17h;
|
92%
|
|
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
N,N-dimethyl-formamide;
at -15 ℃;
for 1h;
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl;
In
N,N-dimethyl-formamide;
at -15 - 12 ℃;
|
88%
|
|
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
N,N-dimethyl-formamide;
at -15 ℃;
for 1h;
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl;
In
N,N-dimethyl-formamide;
at -10 - 12 ℃;
|
88%
|
|
With
sodium hexamethyldisilazane;
In
N,N-dimethyl-formamide;
at -15 - 12 ℃;
|
88%
|
|
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -20 ℃;
for 1h;
Inert atmosphere;
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
|
84%
|
|
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
N,N-dimethyl-formamide;
at -15 ℃;
for 1.5h;
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl;
In
N,N-dimethyl-formamide;
at 12 ℃;
|
|
|
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one;
With
sodium hexamethyldisilazane;
In
N,N-dimethyl-formamide;
at -15 ℃;
for 1h;
2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl;
In
N,N-dimethyl-formamide;
at -10 ℃;
|
|
|
With
tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 17h;
|
17.6 g
|
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C37 H33 F10 NO4
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875446-37-0
anacetrapib
| Conditions | Yield |
|---|---|
|
With
potassium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
Inert atmosphere;
|
89%
|
2.What is the CAS number for Anacetrapib ?
The CAS number of Anacetrapib is 875446-37-0.
More information of Anacetrapib 875446-37-0 are:
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CAS?Number |
875446-37-0 |
|
Density |
1.345 g/cm3 |
|
Boiling Point |
555.309 °C at 760 mmHg |
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Flash Point |
289.641 °C |
|
PSA |
38.77000 |
|
LogP |
9.70100 |
|
Pka |
-2.30±0.60(Predicted) |
3.What are another words for Anacetrapib ?
Synonyms?for?Anacetrapib 875446-37-0:(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one
4.What is the molecular formula of Anacetrapib?
The chemical formula of ?Anacetrapib is?C30H25F10NO3 which containing 30 Carbon atoms,25 Hydrogen atoms,10 Fluorine atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??Anacetrapib?is 637.517.
5.What is Anacetrapib (875446-37-0) used for?
Anacetrapib is an orally active and potent cholesterol ester transfer protein (CETP) inhibitor, which is used for the treatment of atherosclerosis, particularly dyslipidemia.
Relevant articles related to Anacetrapib:
|
Article |
Source |
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Preparation method of Anacetrapib |
- Paragraph 0041; 0053; 0054, (2017/08/28) |
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CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE ANTI-1,2-NITROALKANOL COMPOUND |
- , (2016/01/12) |
6.Buy Anacetrapib with the best price .
Shenzhen Konrad Biological Technology Co., LTd is a quality supplier of Anacetrapib. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Anacetrapib 875446-37-0.